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Plant-based cattle vaccine scaled in plant cell culture - Kristin's Publication

posted Apr 20, 2015, 11:00 AM by Wayne Curtis
Congratulations to Kristin O'Neill and her Undergraduate helpers ... as this paper was a 'side project' that was left on a back-burner for nearly a decade as we dealt with a broadening of the labs research focus.  The basic concept is to utilize transgenic plant material expressing a vaccine epitope for pathogenic E.coli as basis for animal vacination when they eat it.  The scaling work was done in a 60L pilot plant bioreactor.  Scale-up of transgenic tobacco cells that express intimin of enterohemorrhagicEscherichia coli O157:H7 for use as a transitional platform for an oral cattle vaccine.